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Treating Behavior Problems in Cats

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Medicines for Treating Sudden Severe Fear, or Aggression continued...

Side Effects

Benzodiazepines can increase appetite and sleeplessness. They can also interfere with learning and memory, so they aren’t good choices for long-term use with DSCC.

Health Issues

Benzodiazepines are metabolized in the liver and excreted through the kidneys of a cat, so if your veterinarian advises you to treat your cat with BZs, he should check your cat’s liver and kidney function with a simple blood test. If your cat has had problems with her kidneys or liver in the past, be sure to let your veterinarian know.

Medicines for Treating Ongoing Behavior Problems

Behavior problems that involve day-to-day household issues, such as problems between multiple cats within a household, or ongoing problems, such as excessive grooming, are best treated with medicines that are given long term, such as TCAs, MAOIs and SSRIs.

Tricyclic Antidepressants

Tricyclic antidepressants (TCAs) were first used to treat depression in people. They work primarily by increasing serotonin and norepinephrin-two neurotransmitters that are involved in regulation of emotional activity. They also affect other neurochemicals involved in emotional reactivity. The TCAs prescribed most for cats are amitriptyline (Elavil® or Tryptanol), clomipramine (Anafranil® or Clomicalm®), doxepin (Aponal®), imipramine (Antideprin or Deprenil), desipramine (Norpramin® or Pertofrane) and nortriptyline (Sensoval). Every cat is unique behaviorally and physiologically, so while one TCA might not work well for your cat, another TCA could have excellent results.

Although TCAs were originally intended to treat depression in people, they can also reduce anxiety, manage compulsive behavior and help people with anger problems. They’ve been used successfully in cats to help treat compulsive behavior problems like excessive grooming, reduce reactivity to other cats in the household and treat anxiety problems.

Dosage Schedule

TCAs are prescribed for use every day. If the medicine isn’t taken every day, it won’t work to treat the behavior problem. TCAs are not usually effective the first day-or even the first few days-that they’re taken. Because at least some of their effectiveness comes from the changes they make to the brain, TCAs must be taken for at least two to three weeks before they produce results. Treatment should continue for at least two months before a decision is made regarding the success of the drug.

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