Feline panleukopenia, also called
feline infectious enteritis, is a leading cause of death in kittens. It has
been called feline distemper, but it bears no relation to the virus that causes
distemper in dogs. There may, however, be crossover infectivity between cats
and the newer forms of parvovirus isolated in dogs.
Panleukopenia virus is present wherever there are susceptible animals. Mink,
ferrets, raccoons, and wild cats all serve as a reservoir. The virus is highly
contagious. It is spread by direct contact with infected animals or their
secretions. Contaminated food dishes, bedding, litter boxes, and the clothes or
hands of people who have treated an infected cat are other routes of
The most common cause of liver failure in cats is idiopathic hepatic lipidosis. The next most
common cause is cholangiohepatitis. Infectious diseases that involve the liver
include feline infectious peritonitis and toxoplasmosis.
and cancers that begin in the liver or spread there from other locations are
other causes of liver insufficiency.
The panleukopenia virus has a special affinity for attacking white blood
cells. The reduction of circulating white cells (leukopenia) gives the disease
its name. Signs of acute illness appear two to ten days after exposure. Early
signs include loss of appetite, severe apathy, and fever up to 105°F (40.5°C).
The cat often vomits repeatedly and brings up frothy, yellow-stained bile. The
cat may be seen crouching in pain, his head hanging a few inches over the
surface of the water bowl. If he is able to drink, he immediately vomits. With
pain in the abdomen, the cat cries plaintively.
Diarrhea may appear early in
the course of the disease, but frequently comes on later. The stools are yellow
or blood-streaked. In young kittens (and some older cats), the onset can be so
sudden that death occurs before the owner realizes the cat is ill. It may seem
as if the cat was poisoned.
Panleukopenia can be transmitted to kittens both before and shortly after
birth. In such cases, the mortality rate is 90 percent. Kittens recovering from
neonatal infection may have cerebellar brain damage and exhibit a wobbly,
jerky, uncoordinated gait that is noted when they first begin to walk.
Secondary bacterial infections are common. The bacterial infection, rather than
the virus itself, may be the cause of death.
A white blood cell count confirms the diagnosis. In-office tests for canine
parvovirus will also detect feline panleukopenia virus, which is a member of
the parvovirus family.
Cats who survive are solidly immune to reinfection but can shed the virus
for several weeks. Along with asymptomatic carriers, this leads to repeated
exposure in a population of cats. The repeated exposure helps to boost immunity
among cats who have already acquired protective antibodies, by continuing to
stimulate their immune systems.
Treatment: Detecting panleukopenia early in the course of the illness is of
prime importance, because intensive treatment must be started at once to save
the cat’s life. It is better to consult your veterinarian on a false alarm than
to wait until the cat is desperately ill. Supportive measures include fluid
replacement, antibiotics, maintaining
nutrition, and, occasionally, blood transfusions.
Prevention: The panleukopenia virus is hardy. It can survive in carpets,
cracks and furnishings for more than a year. It is resistant to ordinary
household disinfectants but can be destroyed using a bleach solution (diluted
with water at 1:32).
Most cats are exposed to panleukopenia sometime during their life.
Vaccination is the most effective way to prevent serious infection.
WebMD Veterinary Reference from "Cat Owner's Home Veterinary Handbook"